Molecular Recognition and Quantification of MLH1, MSH2, MSH6, PMS2, and KRAS in Biological Samples

Two stochastic sensors based on modification of nitrogen and boron dopped exfoliated graphene with a complex protoporphyrin cobalt, were used for molecular recognition quantification MLH1, MSH2, MSH6, PMS2 KRAS biomarkers in biological samples (whole blood, urine, saliva, tumoral tissue). Limits determination fg ml ?1 magnitude order broad linear concentration ranges favorized their from very low to higher concentrations samples. The student t-test showed that there is no significant difference between the results obtained by utilizing two microsensors screening tests, at 99% confidence level, being lowr than tabulated value.