Molecular signatures for vaccine development
نویسندگان
چکیده
منابع مشابه
Molecular and cellular signatures of human vaccine adjuvants.
Oil-in-water emulsions are potent human adjuvants used for effective pandemic influenza vaccines; however, their mechanism of action is still unknown. By combining microarray and immunofluorescence analysis, we monitored the effects of the adjuvants MF59 oil-in-water emulsion, CpG, and alum in the mouse muscle. MF59 induced a time-dependent change in the expression of 891 genes, whereas CpG and...
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“Molecular signatures” or “gene-expression signatures” are used to model patients’ clinically relevant information (e.g., prognosis, survival time) using expression data from coexpressed genes. Signatures are a key feature in cancer research because they can provide insight into biological mechanisms and have potential diagnostic use. However, available methods to search for signatures fail to ...
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ژورنال
عنوان ژورنال: Vaccine
سال: 2015
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2015.03.075