Moment Analysis of Mass Transfer Kinetics in Micellar Electrokinetic Chromatography Systems

Micellar electrokinetic chromatography.

Analysis of oseltamivir in Tamiflu capsules using micellar electrokinetic chromatography.

A simple and rapid micellar electrokinetic chromatography (MEKC) method was developed for the analysis of an antiviral drug, oseltamivir, and its hydrolyzed product in Tamiflu capsules. Background electrolytes consisted of boric acid 10 mM, pH 10, and sodium dodecyl sulphate (SDS) 40 mM. The limit of detection (LOD) and limit of quantification (LOQ) of oseltamivir were 1.7 and 8.0 microg/ml, re...

Principles of micellar electrokinetic capillary chromatography applied in pharmaceutical analysis.

Since its introduction capillary electrophoresis has shown great potential in areas where electrophoretic techniques have rarely been used before, including here the analysis of pharmaceutical substances. The large majority of pharmaceutical substances are neutral from electrophoretic point of view, consequently separations by the classic capillary zone electrophoresis; where separation is base...

Retention indices in micellar electrokinetic chromatography

The use o f retent ion indices in mice l la r electrokinet ic ch roma tog raphy ( M E K C ) is eva lua ted both f rom a theoretical and a practical point o f view. F undamen t a l equa t ions for the de te rmina t ion o f retent ion indices in M E K C are descr ibed, showing that re tent ion indices are independen t o f the surfac tant concentra t ion. Possibi l i t ies as well as l imita t ion...

Fluorescence Imaging Analysis of Transient Trapping–microchip Micellar Electrokinetic Chromatography

This paper reports an fluorescence imaging analysis to verify the proposed mechanisms in transient trapping– microchip micellar electrokinetic chromatography (tr-trapping–MCMEKC). Fluorescence imaging revealed that a process of tr-trapping consisted of four migration stages with different apparent diffusion constants. In the first trapping stage, the diffusion of a focused sample band was suppr...