Monitoring rapid metabolic changes in health and type-1 diabetes with breath acetone sensors

Routine detection of health parameters is desirable to recognize the early onset metabolic diseases (e.g., diabetes mellitus) and personalize their treatment. Promising are non-invasive, affordable portable technologies, such as breath sensors. Yet, selective monitoring markers acetone for lipolysis) with sensors track changes that can reveal disease-related abnormalities remains challenging. Here, subtle during fasting, exercise glucose ingestion tracked in two model situations: Patients suffering from type-1 mellitus (T1DM) healthy subjects (total: 19 volunteers) were monitored using chemoresistive based on Si/WO 3 nanoparticles. Specifically, each subject cycled after overnight fasting stimulate fatty acid oxidation followed by an oral tolerance test (OGTT), capillary blood β-hydroxybutyrate (BOHB) concentrations. The sensor recognized accurately individual patterns before OGTT (both R 2 = 0.9) at negligible interference, instance, ingestion-associated volatiles ethanol) or isoprene, confirmed high-resolution mass spectrometry. Furthermore, distinct differences T1DM over revealed including higher ( t -test, p 0.006) ratio h starting OGTT. Worth noting intake, isoprene steadily increased while it remained rather constant ones, intriguing observation requires more research clarify its biochemical origin medical relevance. • Portable tracks ingestion. Different between revealed. Tested validation spectrometry assay. High selectivity other compounds (e.g. ethanol). Provides personalized feed-back metabolism diseased populations.