Monoamine neurotransmitters modulate NT-3 levels in astrocytes
نویسندگان
چکیده
منابع مشابه
Monoamine neurotransmitters modulate NT-3 levels in astrocytes
Background Neurotrophin-3 (NT-3), a member of the neurotrophin family of neurotrophic factors, displays profound neuromodulatory functions in the normal and in the diseased brain. Under physiological conditions, NT-3 is produced by neuronal cells and also by local glial cells. We focused our investigation on the ability of astrocytes to synthesize NT-3 and, additionally, on the active involveme...
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The plasma membrane monoamine transporter (PMAT) and organic cation transporter 3 (OCT3) are the two most prominent low-affinity, high-capacity (i.e., uptake(2)) transporters for endogenous biogenic amines. Using the Flp-in system, we expressed human PMAT (hPMAT) and human OCT3 (hOCT3) at similar levels in human embryonic kidney 293 cells. Parallel and detailed kinetics analysis revealed distin...
متن کاملEffects of Moxa Smoke on Monoamine Neurotransmitters in SAMP8 Mice
Objectives. To investigate the anti-aging effects of moxa smoke on SAMP8 mice. Methods. Using 2 × 3 factorial design, exposure length (15 or 30 minutes daily), and concentration (low, 5-15 mg/m(3); middle, 25-35 mg/m(3); high, 85-95 mg/m(3)), 70 SAMP8 mice were randomly assigned, n = 10/group, to a model group or one of six moxa smoke groups: L1, L2, M1, M2, H1, or H2. Ten SAMR1 mice were used ...
متن کاملHistamine-neurotrophin-3 interactions in cultured rat astrocytes
Background Neurotrophin-3 (NT-3) is produced by astrocytes, in addition to neurons, and monoamine neurotransmitters play a role in controlling NT-3 synthesis [1]. The impact of histamine on the regulation of NT-3 synthesis in cultured astrocytes has not been studied in detail. Therefore, we focused our present study on the active involvement of multiple histaminergic receptor and intracellular ...
متن کاملA 61 Histamine – neurotrophin - 3 interactions in cultured rat astrocytes
Background Neurotrophin-3 (NT-3) is produced by astrocytes, in addition to neurons, and monoamine neurotransmitters play a role in controlling NT-3 synthesis [1]. The impact of histamine on the regulation of NT-3 synthesis in cultured astrocytes has not been studied in detail. Therefore, we focused our present study on the active involvement of multiple histaminergic receptor and intracellular ...
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ژورنال
عنوان ژورنال: BMC Pharmacology
سال: 2009
ISSN: 1471-2210
DOI: 10.1186/1471-2210-9-s2-a60