Monocyclic and dicyclic hydrocarbons: structural requirements for proximal giant axonopathy
نویسندگان
چکیده
منابع مشابه
Proximal inhibition of p38 MAPK stress signaling prevents distal axonopathy.
The p38 mitogen-activated protein kinase (MAPK) isoforms are phosphorylated by a variety of stress stimuli in neurodegenerative disease and act as upstream activators of myriad pathogenic processes. Thus, p38 MAPK inhibitors are of growing interest as possible therapeutic interventions. Axonal dysfunction is an early component of most neurodegenerative disorders, including the most prevalent op...
متن کاملStructural requirements for auditing educational and research processes (Case: Shahed University)
The present study identified the structural requirements for auditing educational and research processes in universities. The problem posed in this research is the lack of specific and appropriate structural dimensions for educational and research auditing. The study is descriptive and used the exploratory method. Questionnaires were used to collect data. Data analysis revealed that formalizati...
متن کاملStructural Requirements for Pairing
The class II antigens ofthe human MHC are cell surface heterodimers composed of noncovalently linked 35-kD a chains and 29-kD (3 chains . These antigens are present on macrophages, B lymphocytes, and other APC (for review, see reference 1). Class II antigens are capable of binding immunogenic peptides and thereby serve as ligand for the TCR (2, 3) . Recent experiments have demonstrated that cla...
متن کاملDistal axonopathy with structural persistence in glaucomatous neurodegeneration.
An early hallmark of neuronal degeneration is distal transport loss and axon pathology. Glaucoma involves the degeneration of retinal ganglion cell (RGC) neurons and their axons in the optic nerve. Here we show that, like other neurodegenerations, distal axon injury appears early in mouse glaucoma. Where RGC axons terminate in the superior colliculus, reduction of active transport follows a ret...
متن کاملThe Effects of Long-Term, Low-Level Exposure to Monocyclic Aromatic Hydrocarbons on Worker's Insulin Resistance
OBJECTIVES This study was designed to investigate whether long-term, low-level exposure to monocyclic aromatic hydrocarbons (MAHs) induced insulin resistance. METHODS The subjects were 110 male workers who were occupationally exposed to styrene, toluene, and xylene. One hundred and ten age-matched male workers who had never been occupationally exposed to organic solvents were selected as a co...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2006
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-006-0106-4