More Stable, More Estrogenic: The SERM-ERα LBD Complex
نویسندگان
چکیده
منابع مشابه
More stable, more estrogenic: the SERM-ERα LBD complex
Many synthetic selective estrogen receptor modulators (SERMs) have been cocrystallized with the human estrogen receptor α ligand binding domain (ERα LBD). Despite stabilizing the same canonical inactive conformation of the LBD, most SERMs display different ligand-dependent pharmacological profiles. We show here that increased partial agonism of SERMs is associated with increased conformational ...
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ژورنال
عنوان ژورنال: Journal of Biophysical Chemistry
سال: 2011
ISSN: 2153-036X,2153-0378
DOI: 10.4236/jbpc.2011.23029