Morphine induces preconditioning via activation of mitochondrial KCa channels

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Morphine induces preconditioning via activation of mitochondrial KCa channels

PURPOSE Mitochondrial calcium sensitive potassium (mK(Ca)) channels are involved in cardioprotection induced by ischemic preconditioning. In the present study we investigated whether morphine-induced preconditioning also involves activation of mK(Ca) channels. METHODS Isolated rat hearts (six groups; each n = 8) underwent global ischemia for 30 min followed by a 60-min reperfusion. Control an...

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Morphine mimics preconditioning via free radical signals and mitochondrial K(ATP) channels in myocytes.

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Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways.

BACKGROUND Volatile anesthetics induce pharmacological preconditioning in cardiac tissue. The purpose of this study was to test whether volatile anesthetics mediate this effect by activation of the mitochondrial adenosine triphosphate-sensitive potassium (mitoK(ATP)) or sarcolemmal K(ATP) (sarcK(ATP)) channel in rat ventricular myocytes and to evaluate the signaling pathways involved. METHODS...

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ژورنال

عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie

سال: 2010

ISSN: 0832-610X,1496-8975

DOI: 10.1007/s12630-010-9325-1