Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma
نویسندگان
چکیده
منابع مشابه
Accumulation of p53 protein is frequent in ovarian cancers associated with BRCA1 and BRCA2 germline mutations.
BACKGROUND Mutations in the BRCA1 or BRCA2 genes are responsible for up to 95% of hereditary ovarian cancer cases. Both genes function as tumour suppressor genes, and development of a cancer is thought to require an accumulation of somatic genetic events in addition to the inherited germline predisposition. It is unknown whether these somatic events in BRCA associated ovarian cancer are similar...
متن کاملSurvival in Familial, BRCA1-associated, and BRCA2-associated Epithelial Ovarian Cancer
The natural history of hereditary and BRCA1and BRCA2-associated epithelial ovarian cancer may differ from that of sporadic disease. The purpose of this study was to compare the clinical characteristics of BRCA1and BRCA2-associated hereditary ovarian cancer, hereditary ovarian cancer with no identified BRCA1/2 mutation, and ovarian cancer in population-based controls. BRCA1 and BRCA2 mutation te...
متن کاملCancers associated with BRCA1 and BRCA2 mutations other than breast and ovarian.
BACKGROUND Previous studies have reported additional cancers associated with BRCA mutations; however, the type, magnitude of risk, and sex differences remain to be clarified. The purpose of this study was to evaluate the incidence of cancers other than breast and ovarian cancer in known mutation carriers. METHODS An institutional review board-approved study identified 1072 patients who had ge...
متن کاملsequence variants of brca1 and brca2 genes in four iranian families with breast and ovarian cancer
background: brca1 and brca2 genes have been recognized to be responsible for 20-30% of hereditary breast cancers and approximately 50% of familial breast and ovarian cancers. therefore, the demand for brca1 and brca2 mutation screening is rapidly increasing as their identification will affect medical management of people at increased risk. because of high costs involved in analysis of brca1 a...
متن کاملOutcome of BRCA1- compared with BRCA2-associated ovarian cancer: a nationwide study in the Netherlands.
BACKGROUND Recent studies suggested an improved overall survival (OS) for BRCA2- versus BRCA1-associated epithelial ovarian cancer (EOC), whereas the impact of chemotherapy is not yet clear. In a nationwide cohort, we examined the results of primary treatment, progression-free survival (PFS), treatment-free interval (TFI), and OS of BRCA1 versus BRCA2 EOC patients. METHODS Two hundred and for...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Modern Pathology
سال: 2011
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2011.183