Motoneuron output regulated by ionic channels: a modeling study of motoneuron frequency-current relationships during fictive locomotion
نویسندگان
چکیده
منابع مشابه
Modeling the lowering of motoneuron voltage threshold during fictive locomotion.
The excitability of lumbar motoneurons in the cat is increased during fictive locomotion induced by stimulation of the mesencephalic locomotor region (MLR). This change in excitability has previously been demonstrated experimentally. During fictive locomotion: (1) the afterhyperpolarization (AHP) is reduced and (2) the voltage threshold for production of an action potential is lowered. The exci...
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We have developed a single-compartment, electrophysiological, hypoglossal motoneuron (HM) model based primarily on experimental data from neonatal rat HMs. The model is able to reproduce the fine features of the HM action potential: the fast afterhyperpolarization, the afterdepolarization, and the medium-duration afterhyperpolarization (mAHP). The model also reproduces the repetitive firing pro...
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Locomotion is controlled in large part by neural circuits (CPGs) that generate rhythmic stereotyped outputs in the absence of descending or sensory inputs. The output of a neural circuit is determined by the configuration of the circuit, synapse properties, and the intrinsic properties of component neurons. In order to understand how a neural circuit functions component neurons, their connectio...
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Locomotion relies on a precisely timed activation of sets of motoneurons. A fundamental question is how this is achieved. In the lamprey, fin and myotomal motoneurons located on the same side of the spinal cord display alternating activity during straight swimming. The neural mechanism underlying this alternation is studied here during fictive locomotion induced by superfusion with NMDA, or loc...
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Previously, we reported a canonical ensemble model of the heart motoneurons that underlie heartbeat in the medicinal leech. The model motoneurons contained a minimal set of electrical intrinsic properties and received a synaptic input pattern based on measurements performed in the living system. Although the model captured the synchronous and peristaltic motor patterns observed in the living sy...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2018
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00068.2018