Motor overflow in Huntington's disease

Applying Bioinfomatics Strategies in Huntingtons Disease Research

MRI Tz Hypointensities in basal ganglia of premanifest Huntingtons disease

Huntingtin and the molecular pathogenesis of Huntingtons disease

Huntington’s disease (HD) is a late-onset neurodegenerative disorder that is caused by a CAG repeat expansion in the IT15 gene, which results in a long stretch of polyglutamine close to the amino-terminus of the HD protein huntingtin (htt). The normal function of htt, and the molecular mechanisms that contribute to the disease pathogenesis, are in the process of being elucidated. In this review...

A Closer Look at Motor Overflow in Dyslexic

Unintentional movement "overflow" between the hands or "mirror movements" are common in young children, but are generally regarded as indicative of developmental delay in older children. This study was designed to investigate mirror movements in a sample of 23 very poor readers, ages 11-13, with learning disabilities, and in a control group of 48 normal readers, matched for age, sex, and handed...

Practice, progress and future directions for physical therapies in Huntingtons disease.

Physical therapies and exercise may have potential as a disease modifying agent in Huntington's disease (HD) and in recent years, there have been several small scale feasibility studies that have shown benefit as a result of physical interventions. When evaluating complex physical interventions, a phased approach using mixed methodology designs that report specific intervention components, adhe...