Mrp14 Deficiency Ameliorates Amyloid Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing
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چکیده
منابع مشابه
Mrp14 deficiency ameliorates amyloid β burden by increasing microglial phagocytosis and modulation of amyloid precursor protein processing.
Neuroinflammation plays a fundamental role in the pathogenesis of Alzheimer's disease (AD), resulting in the extensive activation of microglial and astroglial cells. Here we describe the role of myeloid-related protein Mrp14, a recently described amplifier of inflammation, in Alzheimer's disease and in the related amyloid precursor protein/presenilin1 (APP/PS1) mouse model. Detection of Mrp14 i...
متن کاملBrief Communications Mrp14 Deficiency Ameliorates Amyloid Burden by Increasing Microglial Phagocytosis and Modulation of Amyloid Precursor Protein Processing
Markus P. Kummer,1 Thomas Vogl,2 Daisy Axt,1 Angelika Griep,1 Ana Vieira-Saecker,1 Frank Jessen,3,4 Ellen Gelpi,5 Johannes Roth,2 and Michael T. Heneka1,4 1Clinical Neurosciences Unit, Department of Neurology, University of Bonn, 53105 Bonn, Germany, 2Institute of Immunology, University of Münster, 48129 Münster, Germany, 3Department of Psychiatry, University of Bonn, 53105 Bonn, Germany, 4Germ...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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Introduction: Iron oxide nanoparticles (Fe2O3-NPs) are small magnetic particles that widely used in different aspects of biology and medicine in modern life. Fe2O3-NP accumulated in the living cells due to absence of active system to excrete the iron ions so damages cellular organelles by highly reactivity. Method: Herein cytotoxic effects of Fe2O3-NP with 50 nm size were investigated on prima...
متن کاملAmyloid precursor protein processing and Alzheimer's disease.
Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau. Genetic, biochemical, and behavioral research suggest that physiologic generation of the neurotoxic Aβ peptide from sequential amyloid precursor protein (...
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ژورنال
عنوان ژورنال: Journal of Neuroscience
سال: 2012
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.1504-12.2012