mTOR
نویسندگان
چکیده
منابع مشابه
mTOR Signaling.
The scarcity of nutrients/energy interspersed with sporadic periods of abundance means that cells must transition between anabolic and catabolic states. An important protein that has evolved to respond to this need is the target of rapamycin (TOR). TOR is a well-conserved serine/ threonine kinase that plays an important role in the signaling network that controls growth and metabolism in respon...
متن کاملP162: Emerging Perspectives on Mtor-Associated Inflammation in Neurodegenerative Diseases
Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...
متن کاملRoles of mTOR and p-mTOR in gastrointestinal stromal tumors.
OBJECTIVE This study aimed to examine the relationship between expression of mammal target of rapamycin (mTOR) and phosphorylation of mTOR (p-mTOR) protein in the PI3K/Akt/mTOR signaling pathways in gastrointestinal stromal tumors and relatiuonships with clinical factors. METHODS Immunohistochemistry was used to detect the expression of the associated proteins mTOR, p-mTOR, and phosphorylatio...
متن کاملmTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
Head and neck cancer is the sixth most common type of Cancer worldwide. Since conventional treatment regimens are nonselective and are associated with systemic toxicities, intense investigations focus on molecular targeted therapy with high selectivity and low adverse effects. mTOR signaling pathway has been found to be activated in head and neck cancer, making it attractive for targeted therap...
متن کاملmTOR inhibitors in sarcoma.
GD Over the last decade, pathology and diagnostics have assumed a new importance in sarcoma. In the past, the belief was that all sarcomas were alike: some were bone sarcomas and some were soft-tissue sarcomas, but it did not matter because the only treatment available if surgery and radiotherapy failed was chemotherapy, and this was only rarely directed at specific subtypes of sarcomas. Some s...
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ژورنال
عنوان ژورنال: médecine/sciences
سال: 2013
ISSN: 0767-0974,1958-5381
DOI: 10.1051/medsci/2013291009