Multidirectional analyses of hepatic chronotoxicity induced by cadmium in mice
نویسندگان
چکیده
منابع مشابه
Monensin ameliorates cadmium-induced hepatic injury in mice, subjected to subacute cadmium intoxication
This study was designed to evaluate the potential application of monensin as an oral drug for the treatment of cadmium-induced hepatic dysfunction. The study was performed using ICR mouse model. Twenty-seven adult ICR male mice were divided into three groups of nine animals each: control (received distilled water and food ad libitum for 28 days); Cd-intoxicated (treated orally with 20 mg/kg b.w...
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Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of Satureja hortensis L. (Lamiaceae family), was evaluated for its activity aga...
متن کاملHistopathological evidences for effect beneficial of Satureja hortensis extract on hepatic lesion by cadmium–induced in Rat
Background & Aim:Cadmium is an important industrial and environmental pollutant. Cadmium is one of the most toxic and carcinogenic heavy metals to organisms. This heavy metal mainly distributes to the liver and kidney in humans and animal and, causing acute hepatic injury. Experimental: The ethanol extract of Satureja hortensis L. (Lamiaceae family), was evaluated for its activity aga...
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Oxidative tissue damage is considered an early sign of cadmium (Cd) toxicity and has been linked with carcinogenesis. Manganese(II)-at low doses, was found to act as a potent antioxidant against oxidative stress in different in vitro systems producing lipid peroxidation conditions. The present study investigates in vivo antioxidant effects of Mn(2+) pretreatment in acute Cd intoxication with re...
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The mechanisms underlying the circadian rhythm of the toxicity induced by irinotecan hydrochloride (CPT-11; 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) were investigated from the viewpoint of the sensitivity of living organisms and the pharmacokinetics of the drug. ICR male mice were housed under standardized light-dark cycle conditions (lights on at 0700, off at 1900) wi...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 2017
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.42.597