Multiple genetic variants explain measurable variance in type 2 diabetes-related traits in Pakistanis
نویسندگان
چکیده
منابع مشابه
Genetics in diabetes: Type 2 diabetes and related traits
The past decade has seen unprecedented progress in the understanding of the genetic basis of type-2 diabetes (T2D), fuelled largely by technological advancement. This has led to large scale studies such as various genome-wide association studies (GWAS). The undercurrent of this book is in defining the genetic basis of T2D and related traits from the perspective of current advancement in genomic...
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BACKGROUND None of the high frequency variants of the incretin-related genes has been found by genome-wide association study (GWAS) for association with occurrence of type 2 diabetes in Japanese. However, low frequency and rare and/or high frequency variants affecting glucose metabolic traits remain to be investigated. METHOD We screened all exons of the incretin-related genes (GCG, GLP1R, DP...
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Epidemiological studies report a high prevalence of type 2 diabetes and metabolic syndrome in the island nation of Mauritius. The Mauritius Family Study was initiated to examine heritable factors that contribute to these high rates of prevalence and consists of 400 individuals in 24 large extended multigenerational pedigrees. Anthropometric and biochemical measurements relating to the metabolic...
متن کاملThe effect of multiple genetic variants in predicting the risk of type 2 diabetes
While recently performed genome-wide association studies have advanced the identification of genetic variants predisposing to type 2 diabetes (T2D), the potential application of these novel findings for disease prediction and prevention has not been well studied. Diabetes prediction and prevention have become urgent issues owing to the rapidly increasing prevalence of diabetes and its associate...
متن کاملCommon Variants in the Adiponectin Gene (ADIPOQ) Associated With Plasma Adiponectin Levels, Type 2 Diabetes, and Diabetes-Related Quantitative Traits
OBJECTIVE Variants in ADIPOQ have been inconsistently associated with adiponectin levels or diabetes. Using comprehensive linkage disequilibrium mapping, we genotyped single nucleotide polymorphisms (SNPs) in ADIPOQ to evaluate the association of common variants with adiponectin levels and risk of diabetes. RESEARCH DESIGN AND METHODS Participants in the Framingham Offspring Study (n = 2,543,...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 2012
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s00125-012-2560-y