Multiple mechanisms of erythromycin resistance
نویسندگان
چکیده
منابع مشابه
Erythromycin resistance in Borrelia burgdorferi.
Susceptibility testing of laboratory strains and clinical isolates of Borrelia burgdorferi indicates that resistance to erythromycin is present in them. Evaluation of the MICs, minimal bactericidal concentrations, and kinetics of bacterial killing of erythromycin suggests that this resistance is increased by preexposure to the antibiotic, is dependent on inoculum size, and may be the result of ...
متن کاملErythromycin resistance by ribosome modification.
Erythromycin inhibits protein synthesis by its effect on ribosome function (14, 118, 119). The metabolic modifications that enable cells to cope with the inhibitory action of erythromycin fall under major headings that include (i) target site alteration, (ii) antibiotic modification, and (iii) altered antibiotic transport. This minireview concentrates on target site alteration, which for erythr...
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The aim of this study was to analyze the distributions of antibiotic susceptibility patterns, serotypes, phenotypes, genotypes, and macrolide resistance genes among 125 nonduplicated erythromycin-resistant Streptococcus pneumoniae clinical isolates collected in a Spanish point prevalence study. The prevalence of resistance to macrolides in this study was 34.7%. Multiresistance (to three or more...
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Multiple myeloma (MM) is predominantly an incurable malignancy despite high-dose chemotherapy, autologous stem cell transplant and novel agents. MM is a genetically heterogeneous disease and the complexity increases as the disease progresses to a more aggressive stage. MM arises from a plasma cell, which produces and secretes non-functioning immunoglobulins. Most MM cells are sensitive to prote...
متن کاملOvercoming multiple drug resistance mechanisms in medulloblastoma
INTRODUCTION Medulloblastoma (MB) is the most common malignant paediatric brain tumour. Recurrence and progression of disease occurs in 15-20% of standard risk and 30-40% of high risk patients. We analysed whether circumvention of chemoresistance pathways (drug export, DNA repair and apoptotic inhibition) can restore chemotherapeutic efficacy in a panel of MB cell lines. RESULTS We demonstrat...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 1990
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/26.4.461