Multiple regulatory roles of Rad9 C-tail in DNA damage responses
نویسندگان
چکیده
منابع مشابه
The contribution of the budding yeast histone H2A C-terminal tail to DNA-damage responses.
The cellular response to DNA damage involves extensive interaction with and manipulation of chromatin. This includes the detection and repair of the DNA lesion, but there are also transcriptional responses to DNA damage, involving the up- or down-regulation of numerous genes. Therefore changes to chromatin structure, including covalent modification of histone proteins, are known to occur during...
متن کاملDNA Damage Responses: Mechanisms and Roles in Human Disease
Significant progress has been made in recent years in elucidating the molecular controls of cellular responses to DNA damage in mammalian cells. Much of our understanding of the mechanisms involved in cellular DNA damage response pathways has come from studies of human cancer susceptibility syndromes that are altered in DNA damage responses. Ataxia-telangiectasia mutated (ATM), the gene mutated...
متن کاملThe BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9–Rad9 interaction after DNA damage
The Saccharomyces cerevisiae checkpoint protein Rad9 is required for transient cell-cycle arrest and transcriptional induction of DNA-repair genes in response to DNA damage [1]. It contains a carboxyterminal tandem repeat of the BRCT (BRCA1 carboxyl terminus) motif, a motif that is also found in many proteins involved in various aspects of DNA repair, recombination and checkpoint control [2][3]...
متن کاملDistinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.
The cellular response to DNA double-strand breaks involves direct activation of ataxia telangiectasia mutated (ATM) and indirect activation of ataxia telangiectasia and Rad3 related (ATR) in an ATM/Mre11/cell-cycle-dependent manner. Here, we report that the crucial checkpoint signalling proteins-p53, structural maintainance of chromosomes 1 (SMC1), p53 binding protein 1 (53BP1), checkpoint kina...
متن کاملMultiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
Mammalian cells are frequently at risk of DNA damage from both endogenous and exogenous sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor and assure the integrity of their genome. In cells, the intact and effective DDR is essential for the maintenance of genomic stability and it acts as a critical barrier to suppress the development of cancer in humans. ...
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ژورنال
عنوان ژورنال: Journal of Rare Diseases Research & Treatment
سال: 2017
ISSN: 2572-9411
DOI: 10.29245/2572-9411/2017/3.1110