Multipotent cells from mammalian iris pigment epithelium

Microcysts of the human iris pigment epithelium.

Microcysts of the iris pigment epithelium have been described in association with diabetes mellitus, systemic mucopolysaccharidoses. Menkes's syndrome, and in neonates. Our study covers 68 cases obtained at necropsy. We specifically examined the iris pigment epithelium for vacuolation. We found that microcysts are more widespread than previously thought. In our series 57.3% of the cases reviewe...

Co-cultivation of retinoblastoma with fibroblasts, iris pigment epithelium, and retinal pigment epithelium in tissue culture.

Retinoblastoma cells of the Y79 line were co-cultivated with human fibroblasts and bovine iris and retinal pigment epithelium in tissue culture. The Y79 cells, which characteristically grow as a suspension culture, were found to attach directly to the fibroblasts and pigment epithelium on the flask surface. Electron microscopic examination of the fibroblast-retinoblastoma co-cultures revealed n...

Cells T + Regulatory Cells; Both Suppress Ctla-4 T + Iris Pigment Epithelium Induce Cd8 + B7

B7+ iris pigment epithelium induce CD8+ T regulatory cells; both suppress CTLA-4+ T cells.

Ocular pigment epithelia contribute to immune privilege by suppressing T cell activation and converting T cells into regulatory T regulatory cells (Tregs) that inhibit bystander T cell activation. Iris pigment epithelium (IPE) does so through direct cell-cell contact with naive T cells, and this suppressive contact is via interactions between B7 expressed constitutively on IPE cells and CTLA-4 ...

Changes in Pigment Epithelium Cells and Iris Pigment Cells of Rana Pipiens Induced by Changes in Environmental Conditions

1. Retina pigment epithelium cells and iris pigment cells are placed in an identical medium. 2. The differentiation into two different parts, as well as the pigment strains of the migrating pigment epithelium cells, is lost. The normally highly specialized cuticular structures disappear. The cells begin to move and assume a spindle shape, thus losing their original hexagonal shape. 3. The migra...