Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices
نویسندگان
چکیده
منابع مشابه
Multiscale model predicts increasing focal adhesion size with decreasing stiffness in fibrous matrices.
We describe a multiscale model that incorporates force-dependent mechanical plasticity induced by interfiber cross-link breakage and stiffness-dependent cellular contractility to predict focal adhesion (FA) growth and mechanosensing in fibrous extracellular matrices (ECMs). The model predicts that FA size depends on both the stiffness of ECM and the density of ligands available to form adhesion...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2017
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1620486114