Muscarinic Toxins from the Black Mamba Dendroaspis polylepis

Muscarinic Toxins from Dendroaspis (Mamba) Venom

Jolkkonen, M., 1996. Muscarinic Toxins from Dendroaspis (Mamba) Venom: Peptides Selective for Subtypes of Muscarinic Acetylcholine Receptors. Acta Univ. Ups., Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 183. 52 pp. Uppsala. ISBN 91-554-3675-7 Snake venoms from various mamba species contain peptides which bind to the muscarinic but not to the nicot...

Black mamba dendroaspis polylepis bite: a case report.

Although very rare in a European context, a bite from the black mamba Dendroaspis polylepis is an event that poses an immediate threat to life. Given the content of neurotoxins in the snake's venom, the mortality of envenomation reaches 100% in almost every case if ventilation is not provided in a timely manner and adequate therapy initiated. The report d...

An Unexpected Case of Black Mamba (Dendroaspis polylepis) Bite in Switzerland

Mambas (genus Dendroaspis) are among the most feared venomous African snakes. Without medical treatment, mamba bites are frequently fatal. First-aid treatment includes lymphatic retardation with the pressure immobilization technique. Medical management comprises continuous monitoring, securing patency of the airway, ensuring adequate ventilation, symptomatic measures, and administration of spec...

Discovery of Peptide-Based Antitoxins against Neurotoxins from Green and Black Mamba (Dendroaspis Family)

The medical threat of mamba envenoming in sub-Saharan Africa revealed by genus-wide analysis of venom composition, toxicity and antivenomics profiling of available antivenoms.

Mambas (genus Dendroaspis) are among the most feared of the medically important elapid snakes found in sub-Saharan Africa, but many facets of their biology, including the diversity of venom composition, remain relatively understudied. Here, we present a reconstruction of mamba phylogeny, alongside genus-wide venom gland transcriptomic and high-resolution top-down venomic analyses. Whereas the g...