Mutual Interactions between Brain States and Alzheimer’s Disease Pathology: A Focus on Gamma and Slow Oscillations
نویسندگان
چکیده
Brain state varies from moment to moment. While brain can be defined by ongoing neuronal population activity, such as oscillations, this is tightly coupled with certain behavioural or vigilant states. In recent decades, abnormalities in have been recognised biomarkers of various diseases and disorders. Intriguingly, accumulating evidence also demonstrates mutual interactions between states disease pathologies: while arise during progression, manipulations modify pathology, suggesting a therapeutic potential. review, focusing on Alzheimer’s (AD), the most common form dementia, we provide an overview how change AD patients mouse models, controlling pathology. Specifically, summarise relationship changes gamma slow oscillations. As pathological these oscillations correlate either pathology models. We argue that neuromodulation approaches target are promising non-pharmacological intervention for neurodegenerative diseases.
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ژورنال
عنوان ژورنال: Biology
سال: 2021
ISSN: ['2079-7737']
DOI: https://doi.org/10.3390/biology10080707