Mycobacterium Tubercular Mediated Inflammation and Lung Carcinogenesis: Connecting Links

Lung cancer is a leading cause of death among all the worldwide and it has highest occurrence mortality rates. <em>Mycobacterium</em> <em>tuberculosis</em> (MTB) induced tuberculosis been known as one risk factors for lung carcinogenesis. The exact mechanism MTB understood to date. Several research epidemiological studies about link between exist. It proposed that causes chronic inflammation, which increases by creating favorable environment. EGFR downstream signaling promotes constitutive activation TKIs domain due mutation in exon 19 21 (L858R point mutation), leads cell proliferation, invasion, metastasis, angiogenesis, causing adenocarcinoma. other have shown human monocyte cells infected enhance invasion induction epithelial-mesenchymal transition (EMT) characteristics co-culture. This review article tried draw relationship