MyD88-induced downregulation of IRAK-4 and its structural requirements

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Clinical features and outcome of patients with IRAK-4 and MyD88 deficiency.

Autosomal recessive interleukin-1 receptor-associated kinase (IRAK)-4 and myeloid differentiation factor (MyD)88 deficiencies impair Toll-like receptor (TLR)- and interleukin-1 receptor-mediated immunity. We documented the clinical features and outcome of 48 patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in 15 countries.The clinical features of IRAK-4 an...

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ژورنال

عنوان ژورنال: FEMS Immunology & Medical Microbiology

سال: 2008

ISSN: 0928-8244,1574-695X

DOI: 10.1111/j.1574-695x.2008.00425.x