Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat
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چکیده
منابع مشابه
Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat.
Uteroplacental insufficiency causes intrauterine growth retardation (IUGR) and subsequent low birth weight, which predisposes the affected newborn towards adult Syndrome X. Individuals with Syndrome X suffer increased morbidity from adult ischemic heart disease. Myocardial ischemia initiates a defensive increase in cardiac glucose metabolism, and individuals with Syndrome X demonstrate reduced ...
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In situ hybridization was used to evaluate patterns of gene expression for glucose transporters 1-4 (GT1-4) in the rat uteroplacenta from the time of implantation through term, and in vivo regional placental glucose metabolism was measured by 14C-labeled 2-deoxyglucose uptake. GT1 mRNA was highly abundant and GT3 was barely detected in the postimplantation decidual reaction. GT1 and 3 mRNAs wer...
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The expression of different glucose transporter isoforms was measured during the development and differentiation of the rat mammary gland. Before conception, when the mammary gland is mainly composed of adipocytes, Glut 4 and Glut 1 mRNAs and proteins were present. During pregnancy, the expression of Glut 4 decreased progressively, whereas that of Glut 1 increased. In the lactating mammary glan...
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Introduction: Diabetes mellitus (DM) is now seen as a worldwide epidemic disease with high prevalence. Exercise training (ET) is known to promote beneficial changes in diabetic patients. The aim of this study was to compare the impact of continuous and intermittent aerobic training on glucose-4 transporter protein (GLUT-4) levels and insulin sensitivity in diabetic rats. Materials and meth...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 2001
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1690373