Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development
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چکیده
منابع مشابه
Myostatin Mutations Cause Double Muscling in Cattle
The differences between humans and farm animals are obvious, from body structure to diet to reproduction. Unlike humans, swine have litters of young; cattle are ruminants; and sheep are woolly. Despite such significant differences, growth and development of mammalian species is very similar. The biological controls that govern the establishment of body axes, induction and morphogenesis of tissu...
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Deletion or inhibition of myostatin in mammals has been demonstrated to markedly increase muscle mass by hyperplasia, hypertrophy, or a combination of both. Despite a remarkably high degree of conservation with the mammalian protein, the function of myostatin remains unknown in fish, many species of which continue muscle growth throughout the lifecycle by hyperplasia. Transgenic rainbow trout (...
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Using a broad-scale automated telemetry array, we explored post-fledging movements of blackpoll warblers breeding in Atlantic Canada. We sought to determine the full spatial scale of post-fledging dispersal, to assess support for three hypotheses for regional-scale post-fledging movement, and to determine whether learning influenced movement during this period. We demonstrated that both young a...
متن کاملDouble muscling in cattle due to mutations in the myostatin gene.
Myostatin (GDF-8) is a member of the transforming growth factor beta superfamily of secreted growth and differentiation factors that is essential for proper regulation of skeletal muscle mass in mice. Here we report the myostatin sequences of nine other vertebrate species and the identification of mutations in the coding sequence of bovine myostatin in two breeds of double-muscled cattle, Belgi...
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Mutations in mitochondrial DNA (mtDNA) have been reported in cancer and are involved in the pathogenesis of many mitochondrial diseases. Uracil-DNA glycosylase, encoded by the UNG1 gene in Saccharomyces cerevisiae, repairs uracil in DNA formed due to deamination of cytosine. Our study demonstrates that inactivation of the UNG1 gene leads to at least a 3-fold increased frequency of mutations in ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2011
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2011.08.027