N-Acetylcysteine augmentation in refractory obsessive–compulsive disorder
نویسندگان
چکیده
منابع مشابه
Memantine augmentation for refractory obsessive-compulsive disorder.
Glutamatergic hyperactivity hypothesis in obsessive-compulsive disorder (OCD) has been proposed but not tested. Memantine is an uncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist. We report two cases of refractory obsessive-compulsive disorder treated with an augmentation of memantine at 15 mg/day. The first case did not benefit from such treatment, while the second showed immediate ...
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objective: glutamate is considered a target for treating obsessive-compulsive disorder (ocd). the efficacy and safety of the nutritional supplement of n-acetylcysteine (nac) as an adjuvant to serotonin reuptake inhibitor (ssri) for treating children and adolescents with ocd has never been examined. methods: this was a 10-week randomized double-blind placebo-controlled clinical trial with 34 ocd...
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N-acetylcysteine (NAC) is a precursor to the amino acid cysteine, a modulator of the glutamatergic system. Thus, NAC may exert a therapeutic effect in several psychiatric disorders, namely schizophrenia and affective disorders, as well as symptoms and syndromes of the obsessiveimpulsive spectrum (e.g., trichotillomania and other grooming disorders, pathological gambling, and substance misuse). ...
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OBJECTIVE In this report, we aimed to evaluate the effect of add-on N-acetylcysteine (NAC) on depressive symptoms and functional outcomes in bipolar disorder. To that end, we conducted a secondary analysis of all patients meeting full criteria for a depressive episode in a placebo controlled trial of adjunctive NAC for bipolar disorder. METHOD Twenty-four week randomised clinical trial compar...
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ژورنال
عنوان ژورنال: Journal of Psychiatry & Neuroscience
سال: 2019
ISSN: 1180-4882
DOI: 10.1503/jpn.180179