Nanodelivery Systems Delivering Hypoxia-Inducible Factor-1 Alpha Short Interfering RNA and Antisense Oligonucleotide for Cancer Treatment

Hypoxia-inducible factor (HIF), which plays a crucial role in oxygen homeostasis, contributes to immunosuppression, tumor angiogenesis, multidrug resistance, photodynamic therapy and metastasis. HIF as therapeutic target has attracted scientists’ strong academic research interests. Short interfering RNA (siRNA) antisense oligonucleotide (ASO) are the more promising broadly utilized methods for oligonucleotide-based therapy. Their physicochemical characteristics such hydrophilicity, negative charge, high molecular weight make them impossible cross cell membrane. Moreover, siRNA ASO subjected rapid deterioration circulation cannot translocate into nuclear. Delivery of specific gene targets should be realized without off-target silencing affecting healthy cells. Nanoparticles vectors delivery possess great advantages flourish research. In this review, we summarized analyzed regulation mechanisms under hypoxia, significant promoting progression, recent on nanoparticle-based cancer immunotherapy, antiangiogenesis, reversal resistance radioresistance, potentiating therapy, inhibiting metastasis proliferation, enhancing apoptosis reviewed thesis. Furthermore, hope provide some rewarding suggestions enlightenments targeting