Nanotherapeutics for autoimmunity becomes mainstream

Green buildings: A niche becomes mainstream

Several compelling factors drive spread of green buildings. Growing tenant demand due to lower operating costs, higher worker productivity and reputational issues forces the real estate sector to adopt efficient building techniques. Overall, operating costs for leadership in Energy and Environmental Design (LEED) certified buildings are 8-9% lower than for regular buildings. Over the life cycle...

miRNA nanotherapeutics for cancer.

MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression through diverse mechanisms. Increasing evidence suggests that miRNA-based therapies, either restoring or repressing miRNA expression and activity, hold great promise. However, the efficient delivery of miRNAs to target tissues is a major challenge in the transition of miRNA therapy to the clinic. Cationic polymers or v...

Targeted nanotherapeutics in cancer

Peptide-siRNA nanotherapeutics in arthritis

RNA interference (RNAi) is a process that involves the delivery of small single stranded RNA molecules into mammalian cells, resulting in the sequence-specific cleavage of complementary mRNA and the silencing of specific gene expression. These small RNA molecules called small interfering RNAs (siRNAs) are the focus of intense research due to their potential therapeutic uses in various disease p...

Shear-activated nanotherapeutics for drug targeting to obstructed blood vessels.

Obstruction of critical blood vessels due to thrombosis or embolism is a leading cause of death worldwide. Here, we describe a biomimetic strategy that uses high shear stress caused by vascular narrowing as a targeting mechanism--in the same way platelets do--to deliver drugs to obstructed blood vessels. Microscale aggregates of nanoparticles were fabricated to break up into nanoscale component...