Nasal adenocarcinomas that closely simulate colonic carcinomas

Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

Advances in genomics in recent years have provided key insights into defining cancer subtypes "within-a-tissue"-that is, respecting traditional anatomically driven divisions of medicine. However, there remains a dearth of data regarding molecular profiles that are shared across tissues, an understanding of which could lead to the development of highly versatile, broadly applicable therapies. Us...

Normal Models that Simulate Dysfunction

Substrate balances across colonic carcinomas in humans.

To investigate the utilization of nutrients by malignant tumors in humans, the balances of energy-yielding substrates and amino acids across colonic carcinomas were assessed in 17 patients during surgery. Blood samples were taken from an artery and the main tumor-draining vein, which was also used for determining tumor blood flow (direct venous outflow technique). Additionally, the substrate ex...

Reflective Simulation - Simulation of Systems That Simulate

The paper is dedicated to simulation of intelligent systems that “imagine” their possible future states by medium of simulation models handled by some of their elements. The reason and importance for simulation of such systems, the techniques for implementing their “nested” simulation models and the obstacles related to the implementation are described and some applications are presented.

Correction: Comparative transcriptomes of adenocarcinomas and squamous cell carcinomas reveal molecular similarities that span classical anatomic boundaries

[This corrects the article DOI: 10.1371/journal.pgen.1006938.].