Natural Compounds Modulating Mitochondrial Functions

Natural Compounds Modulating Mitochondrial Functions

Mitochondria are organelles responsible for several crucial cell functions, including respiration, oxidative phosphorylation, and regulation of apoptosis; they are also the main intracellular source of reactive oxygen species (ROS). In the last years, a particular interest has been devoted to studying the effects on mitochondria of natural compounds of vegetal origin, quercetin (Qu), resveratro...

Mitochondrial Dysfunction in Gliomas: Pharmacotherapeutic Potential of Natural Compounds

Gliomas are the most common primary brain tumors either benign or malignant originating from the glial tissue. Glioblastoma multiforme (GBM) is the most prevalent and aggressive form among all gliomas, associated with decimal prognosis due to it`s high invasive nature. GBM is also characterized by high recurrence rate and apoptosis resistance features which make the therapeutic targeting very c...

Anticancer Natural Compounds: Molecular Mechanisms and Functions. Part I

Anticancer Natural Compounds: Molecular Mechanisms and Functions 
Part II

In spite of enormous success achieved by the cancer biologists and clinical oncologists alike for the last decades, cancers still presents a great challenge for the researchers and suffering for the patients. While basic mechanisms underlying tumor initiation and progression are unraveling as we speak, as well as novel therapeutic strategies often appear in clinical practice the tumors defend t...

Herbal Compounds and Toxins Modulating TRP Channels

Although the benefits are sometimes obvious, traditional or herbal medicine is regarded with skepticism, because the mechanism through which plant compounds exert their powers are largely elusive. Recent studies have shown however that many of these plant compounds interact with specific ion channels and thereby modulate the sensing mechanism of the human body. Especially members of the Transie...