Negative studies shape the state of sickle trait
نویسندگان
چکیده
منابع مشابه
Negative studies shape the state of sickle trait.
Currently in the United States, people with SCT may be identified through mandated state newborn screening programs or athletic association screening. However, despite widespread screening recommendations, clear guidelines regarding follow-up, counseling, and management of individualswithSCTdonot exist secondary to a paucity of data fromwell-designed studies. This research void in SCT is partic...
متن کاملMechanistic Studies of the Negative Epistatic Malaria-protective Interaction Between Sickle Cell Trait and α+thalassemia
BACKGROUND Individually, the red blood cell (RBC) polymorphisms sickle cell trait (HbAS) and α+thalassemia protect against severe Plasmodium falciparum malaria. It has been shown through epidemiological studies that the co-inheritance of both conditions results in a loss of the protection afforded by each, but the biological mechanisms remain unknown. METHODS We used RBCs from >300 donors of ...
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BACKGROUND Sickle cell trait (SCT) is the heterozygous form of sickle cell disease and expectedly should be a benign state with no complications ascribed to it. There are numerous reports challenging its being a benign condition, though this is controversial. METHODS AND RESULTS A review of the results of the accompanying investigations done on some of the patients show that beta thalassemia ...
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چکیده ندارد.
15 صفحه اولPrevalence of sickle cell disease and sickle cell trait in national neonatal screening studies
UNLABELLED Sickle cell anemia is the best known hereditary blood disorder; there are serious complications associated with the condition. Diagnosis and early intervention reduce morbidity and mortality. These benefits have resulted in the widespread use of newborn screening education programs. In Brazil, the National Neonatal Screening Program established by decree 822/01 included sickle cell d...
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ژورنال
عنوان ژورنال: Blood
سال: 2017
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2016-12-753400