Neoadjuvant Chemoradiation Compared With Neoadjuvant Radiation Alone in the Management of High-Grade Soft Tissue Extremity Sarcomas
نویسندگان
چکیده
منابع مشابه
Neoadjuvant Chemoradiation Herapy for Soft Tissue Sarcomas of the Extremities
INTRODUCTION AND OBJECTIVE Neoadjuvant and adjuvant therapies for soft tissue sarcomas of the extremities are still controversial. The aim of this study was to analyze the results of a protocol of neoadjuvant chemoradiation therapy for extremity sarcomas. METHODS A retrospective analysis was carried out in a consecutive series of 49 adult patients with advanced extremity soft tissue sarcomas ...
متن کاملNeoadjuvant chemoradiation compared to neoadjuvant radiation alone and surgery alone for Stage II and III soft tissue sarcoma of the extremities
BACKGROUND Neoadjuvant chemoradiation (NCR) prior to resection of extremity soft tissue sarcoma (STS) has been studied, but data are limited. We present outcomes with NCR using a variety of chemotherapy regimens compared to neoadjuvant radiation without chemotherapy (NR) and surgery alone (SA). METHODS We conducted a retrospective chart review of 112 cases. RESULTS Treatments included SA (3...
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to define efficacy of pre-operative chemotherapy in down staging of advanced non-round cell soft tissue sarcomas. from sep 2002 to dec 2005, 70 patients were treated by ifosfamid, mesna, cisplatin, adriamycin, mitomycin and subsequent surgery. postoperatively, patients received radiotherapy in cases of microscopically incomplete resection or local recurrence. the median age of the patients was ...
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Together with surgery and radiotherapy, systemic treatment with cytotoxic chemotherapy and molecular targeted agents is one of the main therapeutic pillars in the treatment of soft-tissue sarcomas and is the mainstay of treatment in patients with advanced or metastatic disease. Unlike other more common malignancies such as breast and colorectal cancer, the role of chemotherapy when used in the ...
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This article provides an understanding of the evaluation, staging, and management of patients with extremity soft tissue sarcoma. Although there are straightforward guidelines to the management of patients with extremity soft tissue sarcoma, each patient presents with a unique tumor, and considerations for tumor control, functional outcome, and the toxicity of therapy must be considered. As is ...
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ژورنال
عنوان ژورنال: Advances in Radiation Oncology
سال: 2020
ISSN: 2452-1094
DOI: 10.1016/j.adro.2019.08.015