Nesprin interchain associations control nuclear size
نویسندگان
چکیده
منابع مشابه
Nesprin-2 mediated nuclear trafficking and its clinical implications
Nuclear translocation of proteins has a crucial role in the pathogenesis of cancer, Alzheimer disease and viral infections. A complete understanding of nuclear trafficking mechanisms is therefore necessary in order to establish effective intervention strategies. Here we elucidate the role of Nesprin-2 in Ca(2+)/Calmodulin mediated nuclear transport. Nesprin-2 is an actin-binding nuclear envelop...
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Nesprins form a novel class of nuclear envelope-anchored spectrin-repeat proteins. We show that a direct association of their highly conserved C-terminal luminal domain with the inner nuclear membrane protein Sun1 mediates their nuclear envelope localisation. In Nesprin-1 and Nesprin-2 the conserved C-terminal amino acids PPPX are essential for the interaction with a C-terminal region in Sun1. ...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2012
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-012-1034-1