Neural cell adhesion molecule (NCAM -/- ) null mice show impaired sensitization of the startle response
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منابع مشابه
Expression of neural cell adhesion molecule (NCAM) isoforms in neuroblastoma.
A comparative study on the expression of the neural cell adhesion molecule (NCAM) in human neuroblastoma cell lines and tissues was undertaken. NCAMs are a family of closely related cell surface glycoproteins involved in cell-cell interactions. Using antibodies that recognise distinct epitopes on NCAM, their presence was shown in neuroblastoma, but these studies do not yield any information on ...
متن کاملNeural cell adhesion molecule (NCAM) and myoblast fusion.
Considerable evidence points to an involvement of neural cell adhesion molecule (NCAM) in myoblast fusion. Changes in the level of NCAM expression, isoform specificity, and localization in muscle cells and tissues correspond to key morphogenetic events during muscle differentiation and repair. Furthermore, anti-NCAM antibodies have been shown by others to reduce the rate of myoblast fusion, whe...
متن کاملChanges in neural cell adhesion molecule (NCAM) structure during vertebrate neural development.
Changes in carbohydrate and polypeptide form of the neural cell adhesion molecule (NCAM) have been documented during the development of central nervous system tissue in both chicken and frog. The carbohydrate variations reflect a high and low content of polysialic acid, and for the two vertebrates examined the expression of these forms is similar. At very early stages of neural development NCAM...
متن کاملIdentification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM
The neural cell adhesion molecule NCAM is capable of mediating cell-cell adhesion via homophilic interactions. In this study, three strategies have been combined to identify regions of NCAM that participate directly in NCAM-NCAM binding: analysis of domain deletion mutations, mapping of epitopes of monoclonal antibodies, and use of synthetic peptides to inhibit NCAM activity. Studies on L cells...
متن کاملThe Neural Cell Adhesion Molecule and Heart Development: What is NCAM Doing in the Heart
The neural cell adhesion molecule (NCAM) may be as important in the heart as it is in the nervous system. NCAM is a cell surface glycoprotein which manifests great diversity in polypeptide isoform and glycosylation throughout cardiogenesis as well as neurogenesis. It is expressed on cardiac myocytes in the myocardium and on epicardial and endocardial cells as well as on the components that inne...
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ژورنال
عنوان ژورنال: Genes, Brain and Behavior
سال: 2005
ISSN: 1601-1848,1601-183X
DOI: 10.1111/j.1601-183x.2005.00132.x