Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
نویسندگان
چکیده
منابع مشابه
Review. Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction.
We hypothesize that drug addiction can be viewed as the endpoint of a series of transitions from initial voluntary drug use through the loss of control over this behaviour, such that it becomes habitual and ultimately compulsive. We describe evidence that the switch from controlled to compulsive drug seeking represents a transition at the neural level from prefrontal cortical to striatal contro...
متن کاملNeural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction
We hypothesize that drug addiction can be viewed as the endpoint of a series of transitions from initial voluntary drug use through the loss of control over this behaviour, such that it becomes habitual and ultimately compulsive. We describe evidence that the switch from controlled to compulsive drug seeking represents a transition at the neural level from prefrontal cortical to striatal contro...
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This review discusses the evidence for the hypothesis that the development of drug addiction can be understood in terms of interactions between Pavlovian and instrumental learning and memory mechanisms in the brain that underlie the seeking and taking of drugs. It is argued that these behaviours initially are goal-directed, but increasingly become elicited as stimulus-response habits by drug-as...
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The processes that underlie the pathological pursuit of drugs in addiction and that support the transition from casual drug taking to their compulsive pursuit have recently been proposed to reflect the interaction of two action control processes that mediate the goal-directed and habitual control of actions for natural rewards. Here we describe the evidence for these learning processes, their a...
متن کاملNeural and psychological mechanisms underlying appetitive learning: links to drug addiction.
The complexity of drug addiction mirrors the complexity of the psychological processes that motivate animals to work for any reinforcer, be it a natural reward or a drug. Here, we review the role of the nucleus accumbens, together with its dopaminergic and cortical innervation, in responding to reinforcement. One important contribution made by the nucleus accumbens is to the process through whi...
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ژورنال
عنوان ژورنال: Philosophical Transactions of the Royal Society B: Biological Sciences
سال: 2008
ISSN: 0962-8436,1471-2970
DOI: 10.1098/rstb.2008.0089