Neural stem cells: mechanisms and modeling
نویسندگان
چکیده
منابع مشابه
Signaling mechanisms regulating adult neural stem cells and neurogenesis.
BACKGROUND Adult neurogenesis occurs throughout life in discrete regions of the mammalian brain and is tightly regulated via both extrinsic environmental influences and intrinsic genetic factors. In recent years, several crucial signaling pathways have been identified in regulating self-renewal, proliferation, and differentiation of neural stem cells, as well as migration and functional integra...
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Mechanisms of neural specification from embryonic stem cells.
While embryonic stem (ES) cells have been used for several years to generate specific populations of neural cells in a translational perspective, they have also emerged as a promising approach in developmental neurobiology, by providing reductionist models of neural development. Here we review recent work that indicates that ES-based models are not only able to mimic normal brain development, b...
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ژورنال
عنوان ژورنال: Protein & Cell
سال: 2012
ISSN: 1674-800X,1674-8018
DOI: 10.1007/s13238-012-2033-6