Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing
نویسندگان
چکیده
منابع مشابه
AMPA Receptor Activation Promotes Non-Amyloidogenic Amyloid Precursor Protein Processing and Suppresses Neuronal Amyloid-β Production
Soluble oligomeric amyloid β peptide (Aβ) generated from processing of the amyloid precursor protein (APP) plays a central role in the pathogenesis of Alzheimer's Disease (AD) and through actions at glutamatergic synapses affects excitability and plasticity. The physiological control of APP processing is not fully understood but stimulation of synaptic NMDA receptors (NMDAR) can suppress Aβ lev...
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ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2018
ISSN: 1347-8613
DOI: 10.1016/j.jphs.2018.05.004