Neuro-endocrine basis for altered plasma glucose homeostasis in the Fragile X mouse
نویسندگان
چکیده
منابع مشابه
Effects of Altered Glucose Homeostasis
Previous studies have suggested that alteration in the expression of the insulin-regulatable glucose transporter of muscle (GLUT4 protein) may be an important determinant of insulin action. In the present studies, we have examined GLUT4 mRNA and protein concentrations in muscle after variations in the metabolic status of the intact animal (i.e., 7 d streptozotocin-induced diabetes, 7 d insulin-...
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Altered maturation of the primary somatosensory cortex in a mouse model of fragile X syndrome.
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and results from the loss of the fragile X mental retardation protein (FMRP). Many fragile X-related cognitive and behavioral features emerge during childhood and are associated with abnormal synaptic and cellular organization of the cerebral cortex. Identifying the roles of FMRP in cortical development will p...
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A complete understanding of the molecular mechanisms leading to HIV-associated insulin resistance remains elusive. Complex interrelationships between genetic predisposition, disease-related body changes and multidrug therapy all contribute to alterations in glucose homeostasis. These abnormalities can be differentiated between acute and reversible changes directly induced by HAART medications a...
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This study provides the first description of auditory cortical processing in a mouse model of Fragile X Syndrome (FXS). FXS is a genetic cause of intellectual impairment and is an autism spectrum disorder. Human studies with auditory evoked potentials indicate that FXS is associated with abnormal auditory processing. The Fmr1 knock-out (KO) mouse is a useful model for studying FXS. The KO mice ...
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ژورنال
عنوان ژورنال: Journal of Biomedical Science
سال: 2010
ISSN: 1423-0127
DOI: 10.1186/1423-0127-17-s1-s8