Neurodevelopment, GABA System Dysfunction, and Schizophrenia
نویسندگان
چکیده
منابع مشابه
GABA Targets for the Treatment of Cognitive Dysfunction in Schizophrenia.
Cognitive deficits, including impairments in working memory that have been linked to the prefrontal cortex, are among the most debilitating and difficult to treat features of schizophrenia. Consequently, the identification of potential targets informed by the pathophysiology of the illness is needed to develop novel pharmacological approaches for ameliorating these deficits. Postmortem studies ...
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At the beginning of the 20th century, when neuropathologists had long searched without success for the neural basis of schizophrenia, this field was called a ‘graveyard for neuropathologists ’. This disappointment opened the door for psychiatrists to focus on psychopathology. The discovery of antipsychotic agents in the 1950s provided a clue to understanding the pathology of this difficult dise...
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Although different hypotheses have been formulated to explain schizophrenia pathogenesis, the links between them are weak. The observation that five psychotic patients on chronic warfarin therapy for deep-vein thrombosis showed long-term remission of psychotic symptoms made us suspect that abnormalities in the coagulation pathway, specifically low tissue plasminogen activator (tPA) activity, co...
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Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily functioning. Whereas our understanding of its pathophysiology is limited, postmortem studies suggest that schizophrenia is associated with deficits of GABA-mediated synaptic transmission. A major role of GABA-mediated transmission may be producing synchronized network oscil...
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Synchronization of neuronal activity in the neocortex may underlie the coordination of neural representations and thus is critical for optimal cognitive function. Because cognitive deficits are the major determinant of functional outcome in schizophrenia, identifying their neural basis is important for the development of new therapeutic interventions. Here we review the data suggesting that pha...
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ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2014
ISSN: 0893-133X,1740-634X
DOI: 10.1038/npp.2014.95