Neurogliaform cortical interneurons derive from cells in the preoptic area
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منابع مشابه
Neurogliaform cortical interneurons derive from cells in the preoptic area
Delineating the basic cellular components of cortical inhibitory circuits remains a fundamental issue in order to understand their specific contributions to microcircuit function. It is still unclear how current classifications of cortical interneuron subtypes relate to biological processes such as their developmental specification. Here we identified the developmental trajectory of neurogliafo...
متن کاملA wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area.
GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function. Different classes of interneurons specialize in targeting specific subcellular domains of excitatory pyramidal cells or other interneurons, which provides cortical circuits with an enormous capability for information processing. As in other regions of the CNS, cortical i...
متن کاملThe embryonic preoptic area is a novel source of cortical GABAergic interneurons.
GABA-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Studies over the past 10 years have demonstrated that, in most mammals, interneurons originate during dev...
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The homeobox-encoding gene Prox1 and its Drosophila homologue prospero are key regulators of cell fate-specification. In the developing rodent cortex a sparse population of cells thought to correspond to late-generated cortical pyramidal neuron precursors expresses PROX1. Using a series of transgenic mice that mark cell lineages in the subcortical telencephalon and, more specifically, different...
متن کاملDiverse role of neurogliaform cells in cortical microcircuits
Cortical circuits consist of two major types of neurons: the excitatory pyramidal cells and the inhibitory interneurons. While pyramidal cells mostly do not differ from each other in their morphological and physiological features, interneurons show diversity of great extent. The different interneuron populations can be described with distinct morphology and in accordance with this with distinct...
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ژورنال
عنوان ژورنال: eLife
سال: 2018
ISSN: 2050-084X
DOI: 10.7554/elife.32017