Neuroimaging of mild behavioral impairment: A systematic review

There are many neuroimaging studies of mild behavioral impairment (MBI), but the results have been somewhat inconsistent. Moreover, it remains unclear whether MBI is a risk factor or prodromal symptom dementia. Therefore, systematic review was conducted to summarize and consider dementia in terms its neural correlates. A supported by JSPS Grant-in-Aid for Scientific Research (C) using identified PubMed, PsycINFO, CINAHL, Google Scholar on November 1, 2022. The inclusion criteria were (i) study; (ii) research human subjects; (iii) papers written English; (iv) not case study, review, book, comments, abstract only. Joanna Briggs Institute critical appraisal checklists used assess quality selected studies, 23 structural functional imaging ultimately included review. suggested an association with atrophy hippocampus, parahippocampal gyrus, entorhinal cortex, temporal lobe, whereas indicated involvement altered default mode network, frontoparietal control salience network MBI. limitation use region-of-interest analysis. brain areas detected as correlates considered be alterations early stage each may emerge against background pathological changes