Neuromorphic bioelectronic medicine for nervous system interfaces: from neural computational primitives to medical applications

Renewable dehydrogenase-based interfaces for bioelectronic applications.

Bioelectronic interfaces that establish electrical communication between redox enzymes and electrodes have potential applications as biosensors, biocatalytic reactors, and biological fuel cells. However, these interfaces contain labile components, including enzymes and cofactors, which have limited lifetimes and must be replaced periodically to allow long-term operation. Current methods to fabr...

Neuromorphic neural interfaces: from neurophysiological inspiration to biohybrid coupling with nervous systems.

OBJECTIVE Computation in nervous systems operates with different computational primitives, and on different hardware, than traditional digital computation and is thus subjected to different constraints from its digital counterpart regarding the use of physical resources such as time, space and energy. In an effort to better understand neural computation on a physical medium with similar spatiot...

Neural prosthetic interfaces with the nervous system.

Once damaged, the adult mammalian nervous system is capable of little functional regeneration. Thus, clinical disorders such as deafness, blindness and paralysis have been treated primarily by substitution rather than correction (e.g. teletype for telephone, braille for print, wheelchair instead of walking). However, recent advances in the technology of miniature electronic implants and in the ...

Silicon synapse implements multiple neural computational primitives

Synapses are highly specialized structures that transmit information between neurons. When an action potential generated by a neuron reaches a presynaptic terminal, a cascade of events produces a flow of ionic currents into or out of the postsynaptic neuron’s membrane, with a characteristic time course that can last up to several hundreds of milliseconds.1 Modeling the detailed dynamics of post...

Electroconductive Neural Interfaces for Neural Tissue Applications