Neuropeptide Y in the rostral ventromedial medulla reverses inflammatory and nerve injury hyperalgesia in rats via non-selective excitation of local neurons
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چکیده
منابع مشابه
Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury.
Nerve injury can lead to mechanical hypersensitivity in both humans and animal models, such that innocuous touch produces pain. Recent functional studies have demonstrated a critical role for descending pain-facilitating influences from the rostral ventromedial medulla (RVM) in neuropathic pain, but the underlying mechanisms and properties of the relevant neurons within the RVM are essentially ...
متن کاملTrigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury
BACKGROUND Our previous studies have shown that complete Freund's adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone of the spinal trigeminal nucleus (Vi/Vc) can induce contralateral orofacial hyperalgesia in rat models. We have also shown that contralateral ...
متن کاملIdentification of cardiovascular neurons in the rostral ventromedial medulla in anesthetized rats.
Recent studies have identified a region in the rostral ventromedial medulla (RVMM) of rats that appears to be involved in cardiovascular function. Since these studies used either microinjection of lidocaine or electrical stimulation, the exact contribution of intrinsic neurons as opposed to fibers of passage could not be determined. The present study was performed to map the location of neurons...
متن کاملSubstance P Enhances Excitatory Synaptic Transmission on Spinally 1 Projecting Neurons in the Rostral Ventromedial Medulla After Inflammatory 2 Injury
Substance P Enhances Excitatory Synaptic Transmission on Spinally 1 Projecting Neurons in the Rostral Ventromedial Medulla After Inflammatory 2 Injury 3 Liang Zhang and Donna L. Hammond 4 Departments of Anesthesia and Pharmacology 5 The University of Iowa 6 Iowa City, IA 52242 U.S.A. 7 Abstract: 249 words Introduction: 697 words Discussion: 2142 words 8 Tables: 0 Figures: 8 9 Running Title: Inf...
متن کاملSubstance P enhances excitatory synaptic transmission on spinally projecting neurons in the rostral ventromedial medulla after inflammatory injury.
It has been proposed, but not directly tested, that persistent inflammatory nociception enhances excitatory glutamatergic inputs to neurons in the rostral ventromedial medulla (RVM), altering the activity and function of these neurons. This study used whole cell patch-clamp methods to record evoked excitatory postsynaptic currents (eEPSCs) in spinally projecting RVM neurons from rats injected w...
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ژورنال
عنوان ژورنال: Neuroscience
سال: 2014
ISSN: 0306-4522
DOI: 10.1016/j.neuroscience.2014.04.035