Neuroprotective Effects of Dexmedetomidine
نویسندگان
چکیده
منابع مشابه
Neuroprotective effects of dexmedetomidine against hyperoxia-induced injury in the developing rat brain
Dexmedetomidine (DEX) is a highly selective agonist of α2-receptors with sedative, anxiolytic, and analgesic properties. Neuroprotective effects of dexmedetomidine have been reported in various brain injury models. In the present study, we investigated the effects of dexmedetomidine on hippocampal neurogenesis, specifically the proliferation capacity and maturation of neurons and neuronal plast...
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Dexmedetomidine, the D-enantiomer of medetomidine, is among the most potent sedative drugs known. It is also one of the best understood in terms of its molecular and cellular mechanisms. Its sedative (and probably its neuroprotective) effects are mediated by subtype A of the α2 adrenergic receptor, a G-protein-coupled receptor. Acting as an agonist at this receptor, dexmedetomidine causes numer...
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During cerebral ischaemia, energetic failure of injured cells together with excessive release of glutamate the most common excitatory amino acid in the brain, lead to excitotoxicity and immediate or delayed neuronal death. There is strong experimental evidence to support the neuroprotective role played by anaesthetic agents. Hence, barbiturates, volatile anesthetics or ketamine exhibit signific...
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ژورنال
عنوان ژورنال: THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
سال: 2013
ISSN: 0285-4945,1349-9149
DOI: 10.2199/jjsca.33.392