Neurotoxicity induced by Fluoride in Rat Cerebral Cortex

donepezile prevents morphine-induced apoptosis in rat cerebral cortex

Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

BACKGROUND Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases. OBJECTIVE To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemica...

Calcium-dependent adenylate cyclase from rat cerebral cortex. Reversible activation by sodium fluoride.

The adenylate cyclase activity of a particulate preparation of rat cerebral cortex is comprised of two contributing components, only one of which requires a Ca’+-dependent regulator protein (CDR) for activity. The CDR-dependent component was stabilized by CDR. responded to increasing free Ca’+ concentrations biphasically (activation then inhibition), and was inhibited by high ratios of Mg’+ to ...

Effect of Paraoxon on GABA Uptake by Rat Cerebral Cortex Synaptosomes

Background: It has been suggested that organophosphates may inhibit gamma-aminobutyric acid (GABA) metabolism in synaptosomal preparations. In the present investigation, we have assessed the interaction between paraoxon and the GABA system at synaptic level. Methods: Synaptosomes were prepared from male Wistar rats (200-250 g). Cerebral cortex was dissected and homogenized, then centrifuged at ...

Riluzole prevents morphine-induced apoptosis in rat cerebral cortex.

Neuronal apoptosis has been shown to be associated with the development of tolerance to morphine. In the present study, we investigated the effect of intracerebroventricular (icv) administration of an inhibitor of glutamate release, riluzole, on morphine-induced apoptosis in the rat cerebral cortex. Various groups of rats received either morphine (intraperitoneally, ip) and vehicle (icv) or mor...