Neurotoxins of Bungarus multicinctus venom purification and partial characterization
نویسندگان
چکیده
منابع مشابه
Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom
The venom of the banded krait (Bungarus multicinctus), one of the major venomous species in Taiwan, contains neurotoxic venom proteins (B. multicinctus proteins) that pose a serious medical problem in tropical and subtropical countries. Even though horse-derived serum is an efficient therapy against snake venom, it is associated with a high cost and side effects. Therefore, developing a more co...
متن کاملCorrection for Lee et al., "Production and Characterization of Neutralizing Antibodies against Bungarus multicinctus Snake Venom".
Banded krait (Bungarus multicinctus; BM), one of the major envenomation species in Taiwan, contains neurotoxic venom proteins (BM proteins), that poses a serious medical problem in tropical and sub-tropical countries. Even though horse-derived serum is an efficient therapy against snake venom, it is associated with high cost and side effects. Therefore, developing a more cost-effective alternat...
متن کاملPartial Purification and Characterization of Anticoagulant Factor from the Snake (Echis carinatus) Venom
Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...
متن کاملInhibition of neuronal acetylcholine sensitivity by alpha-toxins from Bungarus multicinctus venom.
Bungarus multicinctus venom contains several alpha-toxins in addition to the widely used alpha-bungarotoxin (Bgt 2.2). We have found that two of the alpha-toxins (Bgt 3.1 and 3.3) inhibit neuronal acetylcholine (AcCho) sensitivity when tested on ciliary ganglion neurons in cell culture. Over 90% of the AcCho sensitivity recorded in response to iontophoretic application of AcCho was blocked when...
متن کاملRecognition of Bungarus multicinctus Venom by a DNA Aptamer against β-Bungarotoxin
Antibody-based technology is the main method for diagnosis and treatment of snake bite envenoming currently. However, the development of an antibody, polyclonal or monoclonal, is a complicated and costly procedure. Aptamers are single stranded oligonucleotides that recognize specific targets such as proteins and have shown great potential over the years as diagnostic and therapeutic agents. In ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 1977
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi00645a031