Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics
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چکیده
منابع مشابه
Neurotransmitter Funneling Optimizes Glutamate Receptor Kinetics
Ionotropic glutamate receptors (iGluRs) mediate neurotransmission at the majority of excitatory synapses in the brain. Little is known, however, about how glutamate reaches the recessed binding pocket in iGluR ligand-binding domains (LBDs). Here we report the process of glutamate binding to a prototypical iGluR, GluA2, in atomistic detail using unbiased molecular simulations. Charged residues o...
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Glutamate is the major excitatory neurotransmitter in the mammalian CNS. Here, we propose a new role for this neurotransmitter in the developing nervous system. We show that glutamate or the metabotropic class I agonist S-3,5-dihydroxyphenyl glycine, acting through the metabotropic glutamate receptor 1 (mGluR1), can reduce the activity of multiple axonal repellents in vitro. This effect is medi...
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ژورنال
عنوان ژورنال: Neuron
سال: 2018
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2017.11.024