Never Will I Ever: Multilevel Mixture Cure Modeling

Finding a cure for HIV: will it ever be achievable?

Combination antiretroviral therapy (cART) has led to a major reduction in HIV-related mortality and morbidity. However, HIV still cannot be cured. With the absence of an effective prophylactic or therapeutic vaccine, increasing numbers of infected people, emerging new toxicities secondary to cART and the need for life-long treatment, there is now a real urgency to find a cure for HIV.There are ...

Language is never , ever , ever , random

Language users never choose words randomly, and language is essentially non-random. Statistical hypothesis testing uses a null hypothesis, which posits randomness. Hence, when we look at linguistic phenomena in corpora, the null hypothesis will never be true. Moreover, where there is enough data, we shall (almost) always be able to establish that it is not true. In corpus studies, we frequently...

Will xenotransplantation ever be feasible?

In several recent conferences, the principal questions have been whether xenotransplantation technology should be encouraged and, if so, how it should be regulated. Because the prospect of successful transplantation of animal organs into humans is still remote, the rush to achieve consensus about clinical application would be inexplicable were it not for two ostensibly unrelated issues. The fir...

'Media will never influence learning': but will simulation?

In this edition of Medical Education, Norman, Dore and Grierson present a review of the association between simulation fidelity and transfer of learning. The review addresses a practical question, references literature from several disciplines, and tackles important limitations in a manner that can enlighten medical educators. In this commentary, we expand upon some of the theories cited with t...

Multilevel Mixture Models