New Computational Tools for Modeling Chronic Myelogenous Leukemia
نویسندگان
چکیده
منابع مشابه
New Computational Tools for Modeling Chronic Myelogenous Leukemia
In this paper, we consider a system of nonlinear delay-differential equations (DDEs) which models the dynamics of the interaction between chronic myelogenous leukemia (CML), imatinib, and the anti-leukemia immune response. Because of the chaotic nature of the dynamics and the sparse nature of experimental data, we look for ways to use computation to analyze the model without employing direct nu...
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We model the immune dynamics between T cells and cancer cells in leukemia patients after a bone-marrow (or a stem-cell) transplant. We use a system of nine delay differential equations that incorporate time delays and account for the progression of cells through different stages. This model is an extension of our earlier model [1]. We conduct a sensitivity analysis of the model parameters with ...
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Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder due to BCR-ABL1 translocation. Patients showing transformation into blast crisis (BC) have poorer treatment response and prognosis. Methods: A retrospective study was conducted in the department of Pathology, Maulana Azad Medical College, New Delhi, India, over a time period of 5 years (2014-2019) to evaluate the ...
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The treatment recommendations for chronic myelogenous leukemia (CML) are evolving rapidly. In the past year, pegylated interferon and STI571 (Gleevec, imatinib mesylate), a Bcr-Abl tyrosine kinase inhibitor, have become commercially available and non-myeloablative stem cell transplants continue to be refined. Clinicians and patients face a bewildering array of treatment options for CML. In this...
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Received for publication 29 September 1980 and in revised form 12 January 198
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ژورنال
عنوان ژورنال: Mathematical Modelling of Natural Phenomena
سال: 2009
ISSN: 0973-5348,1760-6101
DOI: 10.1051/mmnp/20094206