New development of synthetic strategy of biologically active natural products possessing medium-rings.
نویسندگان
چکیده
منابع مشابه
BIOLOGICALLY ACTIVE SYNTHETIC POLYMERSt
The 1:2 divinyl ether-maleic anhydride cyclic alternating copolymer (DIVEMA) shows a wide variety of biological activities. It has antitumor activity; it induces the formation of interferon; it has antiviral, antibacterial, and antifungal activity; it is an anticoagulant and an anti-inflammatory agent. DIVEMA is an immunopotentiator; it increases the rate of phagocytosis, it activates macrophag...
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Our group focuses on synthesising biologically active compounds for the various stages of drug development. Several of our projects are devoted to the development of basic synthetic methodology, with a special emphasis on asymmetric synthesis, while others address the synthesis of compounds of known therapeutic interest, in which emphasis is placed on the reliability, efficiency and scalability...
متن کاملSynthesis of biologically active molecules and development of new synthetic methodologies
Catalytic and asymmetric reactions. Basic synthetic methodologies New developments in the Pauson-Khand reaction The Pauson-Khand reaction (PKR) is one of the most powerful reactions for the preparation of cyclopentanic compounds. The PKR is a cobalt-promoted or -catalysed cycloaddition between an alkene and an alkyne with the insertion of a carbon monoxide molecule to give a cyclopentenone. We ...
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In this study, our previously reported novel synthetic gene encoding 166 residues of interferon-? was used for an efficient expression of IFN-?. The synthetic gene was cloned into pET21a expression vector and transferred into E. coli. Recombinant protein was over-expressed in the E. coli. Identity of the recombinant protein was confirmed by western blot analysis. The recombinant protein was bio...
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Bradykinin, Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg, is released from bradykininogen by the action of kallikreins and brings about smooth muscle stimulation, vasodilation, increase in capillary permeability, ac cumulation and migration of leucocytes and pain production. It is well known that so-called kininase, for example catheptic carboxypeptidase B and carboxypeptidase N, destroy bradykinin by c...
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ژورنال
عنوان ژورنال: Kagaku To Seibutsu
سال: 1987
ISSN: 0453-073X,1883-6852
DOI: 10.1271/kagakutoseibutsu1962.25.575